Evidence records
Claim Ledger
Claims are published with their exact wording, source relationship, limitations, and relevance to The Ice Sack.
01Established PhysiologyTRPM8 is a cold- and menthol-activated ion channel expressed in a subset of sensory neurons and contributes to somatic cold detection.High confidence · Mechanistically Relevant02Research InterpretationWhole-body skin-surface cooling can increase arterial pressure and reduce peripheral and visceral vascular conductance without necessarily changing heart rate.Moderate confidence · Indirect Analogy03Research InterpretationHeart-rate, blood-pressure, and cardiac-autonomic responses to cold exposure vary with the cooling method, exposure conditions, timing, and participant characteristics.Moderate confidence · Indirect Analogy04Research InterpretationCold-delivery methods differ in medium, contact, coverage, temperature profile, and heat-transfer conditions; results from one method should not be assumed to transfer directly to another.High confidence · Mechanistically Relevant05Research InterpretationInteroceptive performance, self-reported interoceptive beliefs, attention, and metacognitive correspondence are related but distinct constructs.High confidence · Not Applicable06Research InterpretationBrief slow-paced breathing can alter heart-rate variability measures associated with cardiac vagal modulation under controlled conditions.Moderate confidence · Indirect Analogy07Research InterpretationFor PCM cooling garments, cooling rate and duration depend on variables including temperature gradient, covering area, PCM mass, and latent heat.Moderate confidence · Indirect Analogy08Research InterpretationSudden cold-water immersion can provoke acute respiratory and cardiovascular responses during the initial exposure period.Moderate confidence · Indirect Analogy09Research InterpretationRepeated cold-water immersion can attenuate parts of the initial cold-shock response under the conditions studied.Moderate confidence · Indirect Analogy10BHVD Conceptual ModelTransfer from Neuropause practice to deliberate state control outside the cold session remains a BHVD research question, not a demonstrated product outcome.No Direct Evidence confidence · Unknown
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