Permanent claim record
Established PhysiologyTRPM8 is a cold- and menthol-activated ion channel expressed in a subset of sensory neurons and contributes to somatic cold detection.
- Statement type
- Established Physiology
- Evidence confidence
- High
- Ice Sack applicability
- Mechanistically Relevant
- Last reviewed
- 2026-08-01
Evidence synthesis
Foundational receptor work identified TRPM8 expression in temperature-sensing neurons and activation by cold and menthol.
Limitations
The source used cellular and sensory-neuron models. It does not determine a person’s subjective experience or establish an Ice Sack outcome.