The Cold Shift

Primary source record · PMID 11893340

A TRP channel that senses cold stimuli and menthol

Andrea M Peier, Aziz Moqrich, Anne C Hergarden, Alison J Reeve, David A Andersson, Gina M Story, Taryn J Earley, Ilaria Dragoni, Peter McIntyre, Stuart Bevan, Ardem Patapoutian

Journal
Cell, 2002
Study type
other
Cold method
unspecified
DOI
10.1016/S0092-8674(02)00652-9

Population

Sensory neurons and heterologous cell expression systems

Exposure conditions

Cold-temperature activation examined in cellular experiments. Not a human exposure protocol.

Outcome measured

TRPM8 expression and activation by cold temperature and menthol

Limitations

Foundational receptor research, not a human intervention and not product evidence.

Open primary recordOpen DOI
TRPM8 is a cold- and menthol-activated ion channel expressed in a subset of sensory neurons and contributes to somatic cold detection.
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